Cpf1 support added to Benchling

Researchers recently discovered a new CRISPR nuclease, Cpf1. Cpf1 is distinct from Cas9 in having an AT-rich PAM (broadening potential targets) and requiring smaller oligos (making it easier to deliver). The study was recently published in Cell.

<img src="/content/images/2015/10/cpf1-1.png" alt="", width="400">

We've also added Cpf1 support to Benchling gRNA design (get started here). Cpf1's PAM (TTTN) is now available in the design tool. The off-target scoring uses a simple function that does not involve positional weights, and will be updated with further research.